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Contraindicated (one)phenobarbital will lessen the level or result of naloxegol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Utilization of naloxegol with solid CYP3A4 inducers just isn't suggestedPharmacokinetics. Barbiturates are absorbed in varying levels subsequent oral or parenteral administration. The salts are m